Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.

Harikumar KB, Sung B, Pandey MK, Guha S, Krishnan S, Aggarwal BB.

Source

Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

Fig. 3E - LPS+Escin, and OA + Escin (lanes 9 and 11) are identical - enhance the contrast to see it.

Fig. 4B - this is a b-actin blot. It is IDENTICAL to a STAT3 loading control used in Figure 2C of PMID 17505005 (Clin Cancer Res. 2007 May 15;13(10):3024-32.). Something is erased from the top right coner in both images, so we know they're the same.

Fig. 6C - A293, b-actin control for TRADD in left side, is the same as b-actin control for p65 on the right side. Blot has been flipped horizontally between conditions.

Fig. 5B - b-actin control in TNF and TNF+Escin is the same, flipped horizontally. There are even vertical shear-lines on this image, so it is impossible to deny they are identical.

Alleged image fraud at MD Anderson Cancer Center (Bharat Aggarwal lab)

2012/02/11