Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1.

Ahn KS, Sethi G, Sung B, Goel A, Ralhan R, Aggarwal BB.

Source

Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

Fig. 4C - enhance the contrast on the lower image - there's a splice between the NC and PC lanes.

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