2012/02/17

Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha.

Oncogene. 2007 Nov 15;26(52):7324-32. Epub 2007 May 28.

Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha.

Sethi G, Ahn KS, Chaturvedi MM, Aggarwal BB.

Source

Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

gure 1C, 1D - b-actin loading control in lanes 1-4 of A, is the same as b-actin in D.

Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis.

Mol Cancer Res. 2008 Jun;6(6):1059-70.

Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis.

Sethi G, Ahn KS, Aggarwal BB.

Source

Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Figure 6B - Panels B1 and B2, same images used for un-treated and TQ treated groups.

Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1.

Mol Pharmacol. 2009 Mar;75(3):525-33. Epub 2008 Dec 22.

Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1.

Pandey MK, Sung B, Ahn KS, Aggarwal BB.

Source

Department of Experimental Therapeutics, Cytokine Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

Figure 1D - Lanes 3 and 4 (10 and 25 dose) are identical to Figure 1G (SCC4 +/-)

Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1.

Mol Cancer Res. 2009 Jan;7(1):118-28.

Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1.

Kunnumakkara AB, Nair AS, Sung B, Pandey MK, Aggarwal BB.

Source

Cytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Figure 2B - STAT3 loading control is identical in left and right panels (IL-6 vs. IL-6+AKBA).
Figure 4A, 4C, 5D - b-actin loading control is the same for all 3 panels.

Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species.

Cancer Res. 2009 Aug 15;69(16):6581-9. Epub 2009 Aug 4.

Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species.

Yodkeeree S, Sung B, Limtrakul P, Aggarwal BB.

Source

Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, 77030, USA.

Figure 3B - DR5 siRNA. "Medium" and "Zerumbone + TRAIL" panels are identical.
Figure 5A - DR4 and DR5 blots, vertical seam between lanes 5 and 6.

Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers.

Biochem Pharmacol. 2010 Jan 15;79(2):218-28. Epub 2009 Aug 12.

Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers.

Tharakan ST, Inamoto T, Sung B, Aggarwal BB, Kamat AM.

Source

Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, United States.

Figure 5A - TUNEL. Curcumin panel is the Vehicle panel, higher intensity and stretched horizontal.

2012/02/11

Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors.

Cancer Res. 2009 Dec 1;69(23):8958-66. Epub 2009 Nov 10.

Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors.

Kamat AM, Tharakan ST, Sung B, Aggarwal BB.

Source

Department of Urology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. akamat@mdanderson.org

Fig. 1A, lower panels (curcumin treated), Medium ad PMN images (panels 1 and 3 in this row) are identical.

Fig. 5B. Curcumin (top right) and BCG (bottom left) have similar areas of image.

Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer.

Int J Cancer. 2010 Jul 15;127(2):257-68.

Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer.

Harikumar KB, Kunnumakkara AB, Sethi G, Diagaradjane P, Anand P, Pandey MK, Gelovani J, Krishnan S, Guha S,Aggarwal BB.

Source

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

Fig. 1C. Counting from the top left, there are 16 panels. Panel #6 and #16 are identical. (11 and 50 are the numbers below these panels).

Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.

Mol Pharmacol. 2010 May;77(5):818-27. Epub 2010 Jan 26.

Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.

Harikumar KB, Sung B, Pandey MK, Guha S, Krishnan S, Aggarwal BB.

Source

Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

Fig. 3E - LPS+Escin, and OA + Escin (lanes 9 and 11) are identical - enhance the contrast to see it.

Fig. 4B - this is a b-actin blot. It is IDENTICAL to a STAT3 loading control used in Figure 2C of PMID 17505005 (Clin Cancer Res. 2007 May 15;13(10):3024-32.). Something is erased from the top right coner in both images, so we know they're the same.

Fig. 6C - A293, b-actin control for TRADD in left side, is the same as b-actin control for p65 on the right side. Blot has been flipped horizontally between conditions.

Fig. 5B - b-actin control in TNF and TNF+Escin is the same, flipped horizontally. There are even vertical shear-lines on this image, so it is impossible to deny they are identical.

Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.

J Biol Chem. 2010 Apr 9;285(15):11498-507. Epub 2010 Feb 12.

Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.

Sung B, Park B, Yadav VR, Aggarwal BB.

Source

Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

b-actin blot in Fig. 1D is the same image as JNK blot in Fig. 5B, stretched vertically.

Fig. 5D - scRNA group, "medium" and "trail" images (1st and 3rd images in this row) are the same.