2012/02/05

J Immunol. 2000;165:5962-9. Cancer Res. 2000;60:3838-47. J Immunol. 2000;164:5815-25. J Immunol. 1999;163:6800-9.

J Immunol. 2000 Nov 15;165(10):5962-9.

Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B,activator protein-1, c-Jun N-terminal protein kinase, and apoptosis.

Manna SK, Mukhopadhyay A, Aggarwal BB.

Cancer Res. 2000 Jul 15;60(14):3838-47.

Oleandrin suppresses activation of nuclear transcription factor-kappaB, activatorprotein-1, and c-Jun NH2-terminal kinase.

Manna SK, Sah NK, Newman RA, Cisneros A, Aggarwal BB.

J Immunol. 2000 Jun 15;164(12):6509-19.

Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygenintermediates and lipid peroxidation.

Manna SK, Mukhopadhyay A, Aggarwal BB.

J Immunol. 2000 Jun 1;164(11):5815-25.

Vesnarinone suppresses TNF-induced activation of NF-kappa B, c-Jun kinase, andapoptosis.

Manna SK, Aggarwal BB.

J Immunol. 1999 Dec 15;163(12):6800-9.

Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis.

Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB.

See two comments on Retraction Watch (MD Anderson investigating researcher Bharat Aggarwal over images) .

If you look back at his publications around 2000, 2001, 2002, there are plenty of issues

http://www.jimmunol.org/content/164/12/6509.long

Somehow they made water soluble resveratrol!

The same control values appear for lipid peroxidation in a few publications too

The crow

February 3, 2012 at5:59 pm

http://www.jimmunol.org/content/164/11/5815.long
http://www.jimmunol.org/content/163/12/6800.long

http://cancerres.aacrjournals.org/content/60/14/3838.long
http://www.jimmunol.org/content/165/10/5962.long

“Untreated cells showed 0.571 ± 0.126 nmol of MDA equivalents/mg of protein” appears in all these papers (unless I’m seeing double, I mean double double). So all the controls have been published multiple times???

the crow

February 4, 2012 at3:49 pm

Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation.

Blood. 2007 Apr 1;109(7):2727-35.

Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation.

Sethi G, Ahn KS, Pandey MK, Aggarwal BB.

Source

Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

Fig.2

See also Abnormal Science Blog ( Like Father Like Son? ).

2012/02/02

Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive andinducible NF-kappaB activity.

Int J Radiat Oncol Biol Phys. 2009 Oct 1;75(2):534-42.

Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive andinducible NF-kappaB activity.

Sandur SK, Deorukhkar A, Pandey MK, Pabón AM, Shentu S, Guha S, Aggarwal BB, Krishnan S.

Source

Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.

Fig. 5

Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products.

Mol Cancer Res. 2010 May;8(5):751-61. Epub 2010 May 11.

Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products.

Harikumar KB, Sung B, Tharakan ST, Pandey MK, Joy B, Guha S, Krishnan S, Aggarwal BB.

Source

Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.